High-Protein Spinach and Artichoke Chicken Casserole (Keto + Low Carb)

Looking for a cozy, satisfying, and high-protein dinner that’s low in carbs but rich in flavor? This Spinach and Artichoke Chicken Casserole is a dream come true for those who want a hearty, cheesy, and nutritious meal without compromising on taste. Inspired by the classic party dip, this casserole brings together juicy shredded chicken, creamy cheese, nutrient-dense spinach, and tender artichokes for a one-pan meal that’s both filling and delicious.

Whether you’re following a keto lifestyle, looking for healthy high protein meals, or simply want a new dinner staple that the whole family will enjoy, this recipe fits the bill perfectly. It’s a satisfying mix of protein, fiber, and healthy fats with irresistible texture and flavor in every bite.

If you’re a fan of comforting dishes like our Garlic Parmesan Chicken Skewers or Crack Breakfast Casserole, you’ll absolutely want to add this to your weekly rotation.

Save

Why You’ll Love This High Protein Dinner

This recipe transforms spinach stuffed chicken into an easy, scoopable casserole. It’s comforting, convenient, and packed with nutrients. The creamy base ensures a rich texture, while the spinach and artichokes add brightness and depth. This dish is naturally low in carbs, making it a favorite among those following low-carb, high-protein, or gluten-free diets.

It’s great for meal prep, can be made ahead of time, and freezes well for future dinners. It’s also an excellent way to sneak more greens into your meals without sacrificing flavor.

Pair this casserole with a simple green salad or roasted vegetables like our Garlic Herb Roasted Potatoes, Carrots, and Zucchini to make a complete and balanced plate.

Ingredients for Spinach Artichoke Chicken Casserole

Here’s everything you’ll need to make this delicious, protein-packed meal:

3 cups cooked chicken, shredded (breasts or thighs)
1 (14 oz) can artichoke hearts, drained and chopped
2 cups fresh spinach, roughly chopped (or 1 cup frozen, thawed and drained)
4 oz cream cheese, softened
½ cup sour cream or plain Greek yogurt
1 cup shredded mozzarella cheese
½ cup grated Parmesan cheese
½ teaspoon garlic powder
½ teaspoon onion powder
Salt and pepper to taste
Optional: red pepper flakes or chopped cooked bacon for extra flavor

Using rotisserie chicken is a great time-saving tip that adds even more flavor. If you’re following strict macros, opt for full-fat dairy and check labels on artichokes to avoid added sugars.

Kitchen Tools You’ll Need

Casserole dish (9×9 or 9×13 depending on thickness)
Large mixing bowl
Wooden spoon or silicone spatula
Measuring cups and spoons
Cutting board and knife
Oven and optional foil for covering

This recipe keeps it simple and doesn’t require any fancy equipment, which is perfect for weeknight cooking.

Save

How to Make Spinach and Artichoke Chicken Casserole

Preheat your oven to 375°F (190°C). Lightly grease your casserole dish with nonstick spray or a thin layer of olive oil.

In a large mixing bowl, combine softened cream cheese, sour cream (or Greek yogurt), garlic powder, onion powder, salt, and pepper. Mix until smooth and creamy.

Add in the shredded chicken, chopped artichokes, spinach, mozzarella, and half of the Parmesan cheese. Stir well until all ingredients are fully incorporated.

Transfer the mixture to your prepared baking dish. Use a spatula to smooth the top evenly. Sprinkle the remaining Parmesan cheese over the surface.

Bake uncovered for 25 to 30 minutes, or until the cheese on top is golden and bubbly. If you like a crispier top, broil for 1 to 2 minutes at the end, watching carefully to prevent burning.

Let the casserole cool slightly before serving. This helps it set and makes it easier to portion.

You can serve this dish as is or pair it with a keto-friendly side like Cauliflower Hash Browns, sautéed green beans, or roasted broccoli. If you’re not watching carbs, it’s fantastic with quinoa or wild rice.

Nutritional Benefits of This Protein-Packed Casserole

This high-protein chicken dinner is full of benefits that support muscle recovery, satiety, and balanced energy. Chicken provides lean protein that’s essential for strength and metabolism. Spinach brings in vitamin K, iron, and magnesium, while artichokes add fiber and antioxidants.

The combination of full-fat dairy and vegetables creates a nutrient-dense meal that fuels your body and satisfies your appetite. It’s ideal for those looking for healthy dinner recipes that align with fitness or weight-loss goals.

If you’re interested in other high-protein options, check out our Protein-Packed Cottage Cheese Egg Bake or Ground Turkey and Peppers Stir Fry for more ideas.

Make It Ahead and Freeze It

This recipe is an excellent option for meal planning. You can assemble the entire casserole up to 24 hours in advance, store it in the refrigerator covered, and bake it when ready. It also freezes beautifully.

To freeze before baking, prepare the casserole in a freezer-safe container and wrap it tightly. Label it with the date and freeze for up to three months. When you’re ready to enjoy it, thaw overnight in the fridge and bake as directed.

To freeze after baking, let the dish cool completely. Cut it into portions and store them in airtight containers. Reheat in the oven or microwave for a quick, satisfying protein-rich lunch or dinner.

Variations and Customizations

This dish is easy to adapt based on your taste or what you have in the kitchen:

Add chopped cooked bacon for smoky flavor and crunch
Use kale or Swiss chard in place of spinach for a hearty twist
Top with sliced fresh tomatoes before baking for a colorful finish
Add chopped mushrooms for an extra layer of savory goodness
Use shredded rotisserie chicken for maximum flavor with minimal effort
Swap the mozzarella for gouda or Monterey jack for a different cheese profile

For a vegetarian spin, try using cooked lentils or chickpeas in place of the chicken, and adjust seasoning to taste.

What to Serve with Spinach Artichoke Chicken Casserole

Although this casserole is satisfying on its own, it pairs well with a variety of sides:

Zucchini noodles or spiralized vegetables for a light, low-carb pairing
Roasted carrots and green beans, like our Honey Glazed Carrots and Green Beans
Fresh arugula salad with lemon vinaigrette for brightness
Steamed cauliflower or Cauliflower Rice for a clean keto-friendly side
Cucumber Dill Salad to add a refreshing, cool contrast

For dessert, follow up with something light and seasonal like our Pumpkin Oatmeal Cookies or Berry Crumble Bars.

Storage and Reheating Tips

Refrigerate leftovers in a sealed container for up to 4 days. Reheat in the microwave or oven. For best results, cover with foil and warm in a 350°F oven for 10 to 15 minutes until heated through.

To freeze leftovers, slice into individual servings and place in freezer-safe containers. When you’re ready to eat, defrost overnight and reheat as needed.

This dish is perfect for taking to work, school, or for a post-workout meal that’s satisfying and energizing.

Save

Frequently Asked Questions

Can I use canned chicken?
Yes, canned chicken works in a pinch. Just be sure to drain it well and fluff it with a fork before mixing.

Is this recipe gluten-free?
Yes, there are no gluten-containing ingredients, making it safe for those with gluten sensitivities.

What can I use instead of sour cream?
Plain Greek yogurt is a great substitute and adds extra protein. You could also try cottage cheese blended until smooth.

Do I need to cook the spinach first?
If using fresh, sautéing or wilting it is helpful, but not mandatory. Frozen spinach should be thawed and squeezed dry.

Can I make this dairy-free?
You can use dairy-free alternatives for the cream cheese, sour cream, and shredded cheeses. Keep in mind that texture and flavor may vary.

A Comforting, High-Protein Casserole You’ll Crave Again and Again

This Spinach and Artichoke Chicken Casserole is more than just a healthy meal—it’s cozy, family-friendly comfort food with serious flavor and nutrition. Whether you’re living the low-carb life or just want a satisfying, protein-packed dinner, this recipe delivers.

It’s quick to prep, versatile enough to customize, and reheats beautifully, making it a perfect option for weekly meal planning. Even picky eaters will find something to love in this cheesy, creamy, veggie-loaded casserole.

If you loved this recipe, be sure to explore more chicken dishes and healthy dinner recipes on our blog. From Chicken Tater Tot Bake to Baked Chicken Legs, we’ve got plenty of ideas to keep your meals exciting.

Don’t forget to bookmark this page, share it with fellow food lovers, and subscribe to the blog for weekly recipes that make healthy eating feel like a treat.

Print