Irresistible Garlic Butter Shrimp Scampi Lasagna Recipe You’ll Crave

Posted on August 4, 2025 ·

By Lyndy

garlic butter shrimp scampi lasagna on a white plate with text overlay

Creamy, savory, and brimming with flavor, this Garlic Butter Shrimp Scampi Lasagna recipe is a standout among seafood entrees. It combines rich garlic butter shrimp with a silky béchamel sauce, all layered between perfectly cooked lasagna noodles. Whether you’re hosting a dinner party or simply treating yourself, this seafood twist on classic lasagna is sure to impress.

Why You’ll Love This Garlic Butter Shrimp Scampi Lasagna Recipe

This lasagna is comfort food with a gourmet edge. The garlic butter enhances the sweetness of the shrimp, while the cheese and cream sauce add luxurious depth. If you enjoy dishes like Creamy Tuscan Salmon or Mediterranean Baked Fish, this lasagna will be right up your alley. It’s approachable, satisfying, and absolutely packed with flavor.

Who This Shrimp Lasagna Recipe is Perfect For

This recipe is perfect for seafood lovers, fans of elevated pasta dishes, and anyone who loves cooking meals that feel special without being complicated. It’s also ideal for:

  • Home chefs looking to explore seafood-based pasta dishes
  • Families who want a seafood dinner that feels indulgent yet familiar
  • Entertainers who want to impress with a restaurant-worthy dish

Essential Ingredients for Garlic Butter Shrimp Scampi Lasagna

Using high-quality, fresh ingredients will ensure that your lasagna stands out.

Ingredients:

  • 1 lb (450g) large shrimp, peeled and deveined
  • 9 lasagna noodles, cooked al dente
  • 3 tablespoons unsalted butter
  • 4 cloves garlic, minced
  • 1 teaspoon red pepper flakes (optional)
  • 1 tablespoon lemon juice
  • 2 tablespoons chopped fresh parsley
  • Salt and black pepper to taste

For the Sauce:

  • 3 tablespoons unsalted butter
  • 3 tablespoons all-purpose flour
  • 2 cups (480 ml) whole milk
  • 1 cup (240 ml) heavy cream
  • 1/2 teaspoon garlic powder
  • 1/2 cup grated Parmesan cheese
  • Salt and black pepper to taste

For Layering:

  • 2 cups shredded mozzarella cheese
  • 1/2 cup grated Parmesan cheese

Kitchen Equipment You’ll Need for Shrimp Scampi Lasagna

To prepare this lasagna seamlessly, make sure you have:

  • Large skillet
  • Medium saucepan
  • 9×13 inch (23×33 cm) baking dish
  • Whisk
  • Measuring cups and spoons
  • Cheese grater
  • Cutting board and knife
  • Mixing spoons
  • Aluminum foil

How to Make Garlic Butter Shrimp Scampi Lasagna: Step-by-Step Preparation

Step 1: Cook the Garlic Butter Shrimp

Melt butter in a skillet over medium heat. Add minced garlic and sauté for 1 minute. Stir in red pepper flakes if you like heat. Add shrimp, season with salt and pepper, and cook for 2–3 minutes per side until pink. Finish with lemon juice and chopped parsley. Remove and set aside.

Step 2: Prepare the Creamy Sauce

In a saucepan, melt butter, whisk in flour, and cook for 1 minute. Slowly whisk in milk and cream, cooking until the mixture thickens. Add garlic powder and Parmesan, then season with salt and pepper. Stir until creamy.

Step 3: Assemble the Lasagna

Preheat oven to 375°F (190°C). Grease a 9×13-inch baking dish. Spread a thin layer of sauce, add 3 noodles, a layer of shrimp, more sauce, and mozzarella. Repeat twice, ending with noodles, remaining sauce, mozzarella, and Parmesan.

Step 4: Bake

Cover with foil and bake for 25 minutes. Uncover and bake 10–15 minutes more until bubbly and golden. Let rest for 10 minutes before slicing.

Pro Tips to Perfect Your Shrimp Scampi Lasagna Every Time

  • Slightly undercook the noodles—they’ll finish in the oven.
  • Don’t overcook shrimp in the pan; they should just turn pink.
  • Fresh parsley or basil adds brightness when sprinkled on top before serving.
  • Want even more seafood inspiration? Try these Baked Garlic Butter Scallops for your next dinner.

Common Mistakes to Avoid When Making Shrimp Lasagna

  • Overcooking the shrimp until they’re rubbery
  • Forgetting to whisk the béchamel sauce continuously, which can lead to clumps
  • Not letting the lasagna rest after baking—it helps everything set and slice cleanly

Serving and Presentation Ideas for Garlic Butter Shrimp Scampi Lasagna

Serve each portion with a touch of fresh parsley and perhaps a lemon wedge. A crisp green salad or Cucumber Dill Salad complements the richness beautifully. You could also serve it with Garlic Parmesan Focaccia for an extra indulgent pairing.

How to Store and Reheat Garlic Butter Shrimp Scampi Lasagna Leftovers

Storage:

  • Refrigerate in an airtight container for up to 3 days.
  • Freeze in individual portions for up to 2 months. Defrost overnight in the refrigerator.

Reheating:

  • Oven: Cover and bake at 350°F (175°C) for 15–20 minutes.
  • Microwave: Reheat in 1-minute intervals, covering loosely.

Delicious Food Pairings for Shrimp Scampi Lasagna

Balance out the creamy richness of the lasagna with refreshing sides like:

Variations & Swaps for Garlic Butter Shrimp Scampi Lasagna

  • Swap shrimp for crab or scallops for a seafood medley.
  • Add sautéed mushrooms or spinach between layers for more texture.
  • Use Gluten-Free Garlic Chicken Lasagna noodles to make it gluten-free.
  • Add lemon zest to the béchamel for a brighter note.

Frequently Asked Questions About Shrimp Scampi Lasagna

Can I prepare the lasagna ahead of time?
Yes, assemble it fully and refrigerate it for up to 24 hours before baking.

Can I use frozen shrimp?
Yes, just thaw completely and pat dry to avoid excess moisture.

Can I substitute store-bought sauce?
You can use a jarred Alfredo sauce, though the homemade version delivers better flavor.

Can I freeze this lasagna?
Definitely. Assemble, wrap tightly, and freeze. Bake from frozen, adding 10–15 minutes.

Final Thoughts + Call to Action

This Garlic Butter Shrimp Scampi Lasagna brings everything you love about classic lasagna together with the irresistible charm of seafood. Perfect for family dinners or special occasions, it’s rich, flavorful, and completely satisfying.

If you loved this recipe, be sure to share it on your social media and subscribe to our blog for more unique and delicious recipes. You might also enjoy our Blackened Mahi Mahi or try your hand at Easy Homemade Sushi Rolls for your next seafood adventure.

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Garlic Butter Shrimp Scampi Lasagna


  • Author: Lyndy
  • Total Time: 1 hour 10 minutes
  • Yield: 6 servings 1x

Description

Garlic Butter Shrimp Scampi Lasagna is a creamy, cheesy, and luxurious seafood pasta bake that blends garlicky shrimp with a velvety cheese sauce and tender noodles. Perfect for special occasions or cozy family dinners, this dish is easy to assemble and packed with gourmet flavor.


Ingredients

Scale
  • For the Garlic Butter Shrimp:
  • 1 lb medium shrimp (peeled, deveined)
  • 3 tablespoons unsalted butter
  • 1 tablespoon olive oil
  • 4 garlic cloves (minced)
  • 1/4 teaspoon red pepper flakes (optional)
  • 1/2 teaspoon salt
  • 1/4 teaspoon black pepper
  • 1 tablespoon fresh lemon juice
  • 1 tablespoon chopped fresh parsley
  • For the Cheese Sauce:
  • 3 tablespoons unsalted butter
  • 3 tablespoons all-purpose flour
  • 2 cups whole milk, warmed
  • 1 cup grated Parmesan cheese
  • 1/2 teaspoon salt
  • 1/4 teaspoon ground nutmeg (optional)
  • For Assembly:
  • 9 lasagna noodles (cooked al dente)
  • 1 cup shredded mozzarella cheese
  • 1/2 cup ricotta cheese
  • 1/4 cup chopped parsley (for garnish)

Instructions

  1. Preheat oven to 375°F (190°C) and grease a 9×13-inch baking dish.
  2. Cook lasagna noodles in salted water until al dente, then drain and lay flat on parchment paper.
  3. In a skillet, heat olive oil and butter over medium heat. Add garlic and red pepper flakes, cook for 1 minute. Add shrimp, salt, and pepper, and sauté for 3–4 minutes until pink. Stir in lemon juice and parsley. Set aside.
  4. To make cheese sauce, melt butter in a saucepan. Whisk in flour and cook for 1–2 minutes. Gradually add warm milk, whisking until thickened. Stir in Parmesan, salt, and nutmeg. Simmer until smooth.
  5. Spread a little cheese sauce in the baking dish. Layer 3 noodles, 1/3 of the shrimp, dollops of ricotta, cheese sauce, and mozzarella. Repeat for three layers, ending with sauce and mozzarella on top.
  6. Cover with foil and bake for 25 minutes. Remove foil and bake another 10–15 minutes until bubbly and golden. Let rest 10 minutes before serving. Garnish with parsley.

Notes

  • Use freshly grated Parmesan for best flavor and melting.
  • Do not overcook shrimp; they will continue cooking in the oven.
  • Let the lasagna rest before slicing for cleaner portions.
  • Make ahead and refrigerate unbaked lasagna for up to 24 hours.
  • Prep Time: 30 minutes
  • Cook Time: 40 minutes
  • Category: Dinner
  • Method: Baked
  • Cuisine: American

Nutrition

  • Serving Size: 1 slice
  • Calories: 520
  • Sugar: 3g
  • Sodium: 670mg
  • Fat: 32g
  • Saturated Fat: 17g
  • Unsaturated Fat: 15g
  • Trans Fat: 0g
  • Carbohydrates: 33g
  • Fiber: 2g
  • Protein: 30g
  • Cholesterol: 205mg

Keywords: Garlic Butter Shrimp Scampi Lasagna, Shrimp Lasagna Recipe, Seafood Pasta Bake, Shrimp Pasta Recipes, Cheesy Shrimp Lasagna

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