Creamy Alfredo Chicken Lasagna : The Ultimate Comfort Food You’ll Want Every Week

If there’s one dish that brings comfort straight from the oven, it’s Alfredo Chicken Lasagna. Layered with tender shredded chicken, silky ricotta, gooey mozzarella, and creamy homemade Alfredo sauce, this lasagna is pure indulgence. It’s rich without being heavy, cheesy without being greasy, and elegant enough for a dinner party yet simple enough for a busy weeknight.

Whether you’re cooking for family, meal prepping for the week, or hosting friends, this Chicken Alfredo Lasagna recipe promises to become your new go-to favorite.

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The Story Behind Chicken Alfredo Lasagna

Traditional Italian lasagna is built on layers of béchamel and rich meat sauce, but this version takes inspiration from the beloved Chicken Alfredo pasta. Alfredo sauce was born in early 20th-century Rome, when Alfredo di Lelio created it to comfort his pregnant wife—a simple sauce made from butter and Parmesan.

When that iconic sauce met lasagna noodles and tender chicken, a new comfort classic was born: Alfredo Chicken Lasagna. Today, it’s a staple in home kitchens across America—creamy, hearty, and endlessly customizable.

If you love creamy baked dishes, you’ll also adore this Cheesy Pasta Bake with Pumpkin Tomato Sauce—a fall-inspired twist that’s just as cozy and satisfying.

Why You’ll Love This Recipe

• Creamy and cheesy perfection: Every bite melts in your mouth with layers of rich sauce and tender chicken.
• Rotisserie chicken shortcut: Saves prep time without sacrificing flavor.
• Family favorite: Loved by kids and adults alike.
• Make-ahead friendly: Perfect for freezing or meal prepping.
• Customizable: Add spinach, mushrooms, or broccoli for an extra nutrition boost.

For another easy comfort classic, try these flavorful Garlic Parmesan Chicken Skewers—they make a great side or main dish alongside lasagna.

Ingredients for Alfredo Chicken Lasagna

Serves 8

For the Alfredo sauce:

• 4 tbsp (60 g) butter
• 3 cloves garlic, minced
• 2 tbsp all-purpose flour
• 2 cups (480 ml) milk
• 1 cup (240 ml) heavy cream
• 1 ½ cups (150 g) grated Parmesan cheese
• ½ tsp salt
• ¼ tsp black pepper
• ¼ tsp nutmeg (optional, for warmth)

For the lasagna layers:

• 9 lasagna noodles (cooked al dente)
• 3 cups (375 g) shredded cooked chicken (rotisserie works great!)
• 1 cup (250 g) ricotta cheese
• 2 cups (200 g) shredded mozzarella cheese
• ½ cup (50 g) grated Parmesan cheese
• 1 tbsp chopped parsley for garnish

If you enjoy creamy casseroles, don’t miss this Keto Meatball Parmesan Casserole—it has all the cheesy satisfaction with a low-carb twist.

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Kitchen Equipment You’ll Need

• 9×13-inch baking dish
• Large saucepan (for sauce)
• Medium pot (for boiling noodles)
• Mixing bowls
• Whisk and wooden spoon
• Aluminum foil
• Measuring cups and spoons

If you’re a fan of easy one-pan recipes, check out this One-Pot Shrimp and Sausage Jambalaya—a bold, flavorful meal with minimal cleanup.

Step-by-Step Preparation Guide

Step 1: Make the Alfredo Sauce

In a large saucepan, melt butter over medium heat. Add minced garlic and cook until fragrant, about 1 minute. Whisk in flour and cook for another minute to form a roux. Gradually pour in milk and heavy cream while whisking constantly to avoid lumps.

Simmer until the sauce thickens—about 3 to 4 minutes. Stir in Parmesan cheese, salt, pepper, and nutmeg. Remove from heat once the sauce coats the back of a spoon.

Step 2: Prepare the Chicken Mixture

In a bowl, combine shredded chicken with half of the Alfredo sauce. This helps infuse the chicken with flavor and moisture before layering.

Step 3: Assemble the Lasagna

Spread a thin layer of Alfredo sauce on the bottom of the baking dish. Add three lasagna noodles, then layer with half the chicken mixture, a few spoonfuls of ricotta, and a sprinkle of mozzarella and Parmesan.

Repeat layers: noodles, chicken, sauce, and cheese. Finish with a final layer of noodles topped with the remaining Alfredo sauce and a generous amount of mozzarella and Parmesan.

Step 4: Bake Until Bubbly

Cover with foil and bake at 375°F (190°C) for 25 minutes. Remove foil and bake another 15 minutes until golden and bubbling.

Step 5: Rest and Serve

Let the lasagna rest for at least 10 minutes before slicing. Garnish with chopped parsley for a fresh finish.

For another rich baked meal, try Polpettone Americano—an Italian-style meatloaf wrapped in bacon that’s just as comforting.

Tips for the Best Chicken Alfredo Lasagna

1. Use rotisserie chicken for speed: It’s juicy, flavorful, and effortless.
2. Don’t overcook noodles: Slightly firm pasta holds up better when baked.
3. Balance the sauce: The right thickness ensures creamy—not runny—layers.
4. Let it rest: Resting time keeps layers intact when serving.
5. Double the recipe: Make one for now and freeze one for later.

Love easy layered meals? Try this Vegetarian Pasta Primavera—it’s colorful, fresh, and perfect for lighter dinners.

Rotisserie Chicken Shortcut

If you’re pressed for time, Rotisserie Kip (store-bought cooked chicken) makes this dish incredibly fast. Simply shred the meat, discard the skin, and toss with a bit of Alfredo sauce to keep it moist before layering.

This shortcut keeps the flavor rich while saving you 30 minutes of prep time—perfect for busy weeknights or lazy weekends.

Another time-saving dish to try: Crockpot Fajitas—tender, juicy, and full of flavor with almost no effort.

Recipe Variations and Substitutions

• Spinach Alfredo Lasagna: Add sautéed spinach or kale for a veggie boost.
• Broccoli Chicken Alfredo Lasagna: Layer steamed broccoli florets between noodles.
• Low-carb version: Replace noodles with zucchini or cauliflower sheets.
• Ricotta-free version: Substitute with cottage cheese for a lighter texture.
• Three-Cheese Alfredo Lasagna: Combine mozzarella, provolone, and Parmesan for extra indulgence.

If you enjoy versatile dishes, you might also love this Ground Beef Wellington—an elegant, meaty meal wrapped in flaky pastry.

Serving and Presentation Ideas

Slice your Alfredo Chicken Lasagna into squares and serve on warm plates. Drizzle with extra Alfredo sauce and sprinkle with parsley or grated Parmesan.

Pair with:

• Garlic bread or Garlic Parmesan Focaccia Bread
• A light side salad with lemon vinaigrette
• Steamed green beans or roasted carrots

For family gatherings, serve it buffet-style with complementary sides like Honey Glazed Carrots and Green Beans—the sweet-savory combo balances the rich sauce beautifully.

Pairing Ideas (Non-Alcoholic)

Pair this lasagna with refreshing drinks such as:

• Sparkling lemonade
• Cucumber mint water
• Lavender lemonade (Recipe here)

You can also serve a cozy starter like Creamy Mushroom Soup to complete your Italian-inspired meal.

Common Mistakes to Avoid

1. Watery sauce: Thicken Alfredo enough to coat a spoon.
2. Skipping the rest time: Causes messy slices.
3. Overbaking: Can dry out the top layer.
4. Using cold noodles: Always use freshly boiled pasta for better layering.
5. Uneven layering: Spread sauces and fillings evenly for balanced flavor.

For another foolproof bake, try this Cheesy Root Vegetable Gratin—a crispy, creamy side that’s perfect for pairing with lasagna.

Make-Ahead, Storage, and Reheating Tips

Make ahead: Assemble the lasagna up to 24 hours in advance. Cover tightly and refrigerate until ready to bake.

To store: Keep leftovers in an airtight container for up to 4 days in the fridge.

To freeze: Wrap baked lasagna tightly in foil and freeze for up to 3 months. Thaw overnight before reheating.

To reheat: Warm individual portions in the oven at 350°F (175°C) for 15–20 minutes, or in an air fryer for a crispy top.

If you love freezer-friendly meals, try this Vegetable Casserole—easy to prepare and perfect for batch cooking.

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Frequently Asked Questions (FAQ)

1. Can I use jarred Alfredo sauce?
Yes, but homemade sauce tastes fresher. If using jarred, choose a high-quality brand and add garlic or extra cheese to elevate the flavor.

2. Can I freeze the lasagna before baking?
Absolutely. Assemble, cover tightly, and freeze. Bake directly from frozen at 375°F for about 1 hour, covering with foil until heated through.

3. What cheese works best?
Mozzarella and Parmesan are classics, but you can mix in provolone or fontina for extra creaminess.

4. Can I add vegetables?
Yes! Broccoli, spinach, or mushrooms make delicious additions.

5. How do I keep my lasagna from sticking?
Use a nonstick pan or line the bottom with a thin layer of sauce before adding noodles.

Related Pasta and Comfort Food Recipes

If this Chicken Alfredo Lasagna has you craving more comforting dishes, explore these reader favorites:

• Creamy Mushroom Pasta – rich and earthy.
• Stuffed Acorn Squash – hearty and wholesome.
• Pumpkin Chicken Chili – warm and cozy.
• Sweet Potato and Chickpea Curry – creamy and full of spice.

Final Thoughts & Call to Action

This Alfredo Chicken Lasagna is everything you love about comfort food—creamy sauce, melty cheese, and tender layers of pasta that bring everyone to the table. It’s perfect for holidays, family dinners, or any night you want something extra special without extra effort.

The next time you crave a cozy meal that feels like a warm hug, make this lasagna. You’ll see why it’s become a weeknight favorite for home cooks everywhere.

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